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These findings reveal the plasticity of the luminal compartment during tumorigenesis and provide an explanation for cellular heterogeneity within a cancer.

We thank Dr Jeffrey Rosen for critical reading of this manuscript.

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This work was supported in part by funds from NIH CA124820 (to YL) and U54CA149196 (to YL; PI: Stephan Wong); from DOD CDMRP BC085050 (to YL), BC112704 (to YL) and BC073703 (YL); and from the Nancy Owens Memorial Foundation (to YL); as well as by the resources from the Dan L.

Duncan Cancer Center (P30CA125123) and the Lester & Sue Smith Breast Center (P50CA058183 & P50-CA186784).

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